Article Text
PDFReview
Hippo pathway deregulation: implications in the pathogenesis of haematological malignancies
Abstract
The Hippo pathway participates in the regulation of cell proliferation, differentiation and apoptosis. It is composed by a large array of proteins whose deregulation has been associated with pro-oncogenic and antioncogenic processes. The present review focuses on the Hippo pathway signalling network and discusses its dual role in oncogenesis, particularly in haematological malignancies.
- APOPTOSIS
- ONCOGENES
- HAEMATO-ONCOLOGY
- CANCER
- CELL CYCLE REGULATION