Footnotes

• Handling editor Tahir S Pillay.

• Contributors All authors have contributed in (1) the conception or design of the work, or the acquisition, analysis or interpretation of data; (2) drafting the work or revising it critically for important intellectual content; (3) final approval of the manuscript; and (4) agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

• Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

• Competing interests None declared.

• Patient consent Parental/guardian consent obtained.

• Ethics approval CEIC Hospital Clinico Universitario de Valencia.

• Provenance and peer review Not commissioned; externally peer reviewed.