PT  - JOURNAL ARTICLE
AU  - Atkin, N. B.
AU  - Petković, I.
TI  - Variable sex chromatin pattern in an early carcinoma of the bladder
AID  - 10.1136/jcp.26.2.126
DP  - 1973 Feb 01
TA  - Journal of Clinical Pathology
PG  - 126--129
VI  - 26
IP  - 2
4099  - http://jcp.bmj.com/content/26/2/126.short
4100  - http://jcp.bmj.com/content/26/2/126.full
SO  - J Clin Pathol1973 Feb 01; 26
AB  - Sex chromatin studies on squash preparations of a well differentiated transitional cell carcinoma of the bladder without evidence of invasion from a female aged 63 revealed a single body in some regions, but two to four bodies in others. All regions were near diploid according to DNA estimations. Previous observations on a variety of invasive tumours of females showed that the presence of more than one sex chromatin body is generally associated with a high chromosome number. The pattern of two or more bodies in near-diploid cells seen in this non-invasive tumour may therefore characterize an intermediate stage of clonal evolution, eventually resulting in malignancy, when the cell line has not yet achieved the ability to invade or metastasize.