RT Journal Article
SR Electronic
T1 Platelet dynamics in chronic liver disease with special reference to the role of the spleen.
JF Journal of Clinical Pathology
JO J Clin Pathol
FD BMJ Publishing Group Ltd and Association of Clinical Pathologists
SP 367
OP 371
DO 10.1136/jcp.30.4.367
VO 30
IS 4
A1 Toghill, P J
A1 Green, S
A1 Ferguson, F
YR 1977
UL http://jcp.bmj.com/content/30/4/367.abstract
AB In all of 12 patients with chronic liver disease, whose platelet dynamics were investigated by the 51Cr-labelling technique in association with surface counting, platelet survival was reduced and in 11 the splenic platelet pool was increased. Surface counting showed high initial spleen liver ratios in eight patients, and in four there was evidence of progressive destruction of platelets in the spleen. In one patient, subsequently shown to have a hepatoma, progressive accumulation of platelets was noted at the tumour site.