RT Journal Article
SR Electronic
T1 Somatostatin: a paracrine contribution to hypothyroidism in Hashimoto's thyroiditis.
JF Journal of Clinical Pathology
JO J Clin Pathol
FD BMJ Publishing Group Ltd and Association of Clinical Pathologists
SP 764
OP 770
DO 10.1136/jcp.35.7.764
VO 35
IS 7
A1 Dhillon, A P
A1 Rode, J
A1 Leathem, A
A1 Papadaki, L
YR 1982
UL http://jcp.bmj.com/content/35/7/764.abstract
AB Thyroid tissue from 18 consecutive cases of Hashimoto's thyroiditis treated surgically were stained immunohistochemically for neurone specific enolase (NSE), somatostatin, calcitonin and thyroglobulin. Cells staining for NSE and somatostatin were present in 14 cases. In four cases large numbers of cells including oxyphil cells stained for NSE. Consecutive sections showed an identical staining pattern of these cells for somatostatin. Sections stained for calcitonin showed few or no positively staining cells. There were moderate numbers of NSE and somatostatin-containing cells in five of the cases, occasional cells in five and none in four cases. Electron microscopy confirmed neurosecretory-like granules within positively staining cells. Somatostatin is known to inhibit T3 and T4 production or release from thyroid cells by a direct action. We suggest, in Hashimoto's disease, somatostatin in paracrine cells serves as a local inhibitory neuroendocrine effector and could be causally related to the hypothyroid state.