RT Journal Article
SR Electronic
T1 Antibody response to anaerobic coccoid rods in Crohn's disease.
JF Journal of Clinical Pathology
JO J Clin Pathol
FD BMJ Publishing Group Ltd and Association of Clinical Pathologists
SP 1130
OP 1134
DO 10.1136/jcp.39.10.1130
VO 39
IS 10
A1 Bull, K
A1 Matthews, N
A1 Rhodes, J
YR 1986
UL http://jcp.bmj.com/content/39/10/1130.abstract
AB The IgG and IgM specific antibodies against a panel of 23 anaerobic gut bacteria were examined in Crohn's disease, ulcerative colitis, and healthy controls. Four of the organisms, Bifidobacterium bifidum, Coprococcus comes (ME46), Coprococcus comes (Sp4), and Eubacterium limosum gave abnormal antibody titres in Crohn's disease compared with those of controls. In Crohn's disease specific IgG antibodies to three of the organisms were low and the IgM antibodies were higher than those of controls. IgM antibodies were also raised in ulcerative colitis. Antigenic cross reactivity could be shown between some of these organisms. The possible clinical importance of these abnormal antibody responses to specific organisms is unexplained.