RT Journal Article
SR Electronic
T1 Use of monoclonal anti-actin as a megakaryocyte marker in paraffin wax embedded bone marrow biopsy specimens.
JF Journal of Clinical Pathology
JO J Clin Pathol
FD BMJ Publishing Group Ltd and Association of Clinical Pathologists
SP 982
OP 984
DO 10.1136/jcp.42.9.982
VO 42
IS 9
A1 Boqué, C
A1 Pujol-Moix, N
A1 Linde, M A
A1 Murcia, C
A1 Guanyabens, C
A1 Soler, J
YR 1989
UL http://jcp.bmj.com/content/42/9/982.abstract
AB Monoclonal anti-actin was used as a marker of megakaryocytes in Zenker's fixed, paraffin wax embedded bone marrow tissue, using an immunoperoxidase staining method. Twenty bone marrow samples were studied, including controls, and different myeloproliferative and myelodysplastic syndromes. The results were compared with those obtained using factor VIII related antigen (F VIII RAg) immunolabelling. Anti-actin is as good a marker for megakaryocytes as anti-FVIIIRAg and is potentially clinically useful when morphological identification is difficult, when bone marrow aspiration is unsuccessful, or when quantitative evaluation of tissue sections is required.