PT  - JOURNAL ARTICLE
AU  - Nagy, B
AU  - Rigó, J
AU  - Fintor, L
AU  - Karádi, I
AU  - Tóth, T
TI  - Apolipoprotein E alleles in women with severe pre-eclampsia.
AID  - 10.1136/jcp.51.4.324
DP  - 1998 Apr 01
TA  - Journal of Clinical Pathology
PG  - 324--325
VI  - 51
IP  - 4
4099  - http://jcp.bmj.com/content/51/4/324.short
4100  - http://jcp.bmj.com/content/51/4/324.full
SO  - J Clin Pathol1998 Apr 01; 51
AB  - This study investigated the frequency of apolipoprotein E (apoE) alleles among women with severe pre-eclampsia. The presence of the three most common apoE alleles (epsilon 2, epsilon 3, epsilon 4) was determined by polymerase chain reaction-restriction fragment length polymorphism in three groups of white women: non-pregnant healthy (n = 101), pregnant healthy (n = 52), and pregnant with a diagnosis of severe pre-eclampsia (n = 54). The frequency of apo epsilon 2 was highest among women with severe pre-eclampsia (16.6%) followed by non-pregnant women (12.9%), and those experiencing a healthy pregnancy (10.6%). The higher frequency of the apo epsilon 2 allele detected among women with severe pre-eclampsia suggests that apoE may play a role in the development of pre-eclampsia.