RT Journal Article
SR Electronic
T1 Raised serum hCG in a male patient caused by primary jejunal choriocarcinoma.
JF Journal of Clinical Pathology
JO J Clin Pathol
FD BMJ Publishing Group Ltd and Association of Clinical Pathologists
SP 413
OP 415
DO 10.1136/jcp.51.5.413
VO 51
IS 5
A1 Chan, G S
A1 Ng, W K
A1 Chua, D T
A1 Wu, P C
YR 1998
UL http://jcp.bmj.com/content/51/5/413.abstract
AB A rare case of primary choriocarcinoma of the jejunum occurred in a 45 year old Chinese man. This tumour was associated with massive melaena and a markedly raised serum human chorionic gonadotrophin (beta-hCG) concentration. Necropsy examination showed no primary lesion in other possible sites including testes, mediastinum, and pineal gland. Histologically, the tumour showed morphology typical of choriocarcinoma with no adenocarcinomatous element identified. The presence of choriocarcinoma in non-gonadal sites may be explained by retrodifferentiation or metaplasia of a conventional carcinomatous component to primitive trophoblasts. Serum beta-hCG level may represent a useful marker in earlier diagnosis and monitoring of this potentially treatable disease.