RT Journal Article
SR Electronic
T1 Unusual manifestations of type II cryoglobulinaemia associated with Waldenström's macroglobulinaemia
JF Journal of Clinical Pathology
JO J Clin Pathol
FD BMJ Publishing Group Ltd and Association of Clinical Pathologists
SP 882
OP 884
DO 10.1136/jcp.53.11.882
VO 53
IS 11
A1 Blanco, P
A1 Viallard, J-F
A1 Rivel, J
A1 Leng, B
A1 Pellegrin, J-L
YR 2000
UL http://jcp.bmj.com/content/53/11/882.abstract
AB Cryoglobulinaemia in association with Waldenström's macroglobulinaemia is relatively common, ranging from 8% to 18% of cases; however, < 5% have symptoms or complications. We describe a patient with a history of cutaneous, peritoneal, and fallopian tube vasculitis related to type II cryoglobulinaemia associated with Waldenström's macroglobulinaemia. Cytotoxic treatment was initiated (cyclophosphamide, vincristine, and prednisone) and had a good initial response. However, after the third course of chemotherapy, the patient presented with septic shock and died. Even though cryoglobulinaemia is a model of systemic vasculitis, peritoneal and fallopian tube vasculitis associated with type II cryoglobulinemia has not been described previously.