PT  - JOURNAL ARTICLE
AU  - Drut, R M
AU  - Drut, R
TI  - Extracutaneous infantile haemangioma is also Glut1 positive
AID  - 10.1136/jcp.2003.012682
DP  - 2004 Nov 01
TA  - Journal of Clinical Pathology
PG  - 1197--1200
VI  - 57
IP  - 11
4099  - http://jcp.bmj.com/content/57/11/1197.short
4100  - http://jcp.bmj.com/content/57/11/1197.full
SO  - J Clin Pathol2004 Nov 01; 57
AB  - Aim: To investigate whether extracutaneous infantile haemangioma-like tumours are immunohistochemically similar to cutaneous infantile haemangiomas. Methods: Mammary, salivary gland, liver (one each), and placental (two cases) capillary haemangiomas and typical examples of cutaneous (eight cases) infantile haemangioma were investigated immunohistochemically for α smooth muscle actin and Glut1, a proposed marker for the skin localised lesion. Positive internal controls included red blood cells, perineurium, trophoblast, and endothelial cells of the placental capillaries. Extralesional vessel endothelium acted as a negative control (except in the placenta). The liver haemangioma and both chorioangiomas presented in patients with Beckwith-Wiedemann syndrome. Results: The endothelial cells of all the vascular lesions were Glut1 positive. These were consistently surrounded by a rim of α smooth muscle actin positive pericytic cells. Controls reacted appropriately. Conclusions: All infantile haemangiomas were immunohistochemically positive for Glut1: expression of this molecule was not limited to infantile haemangiomas of the skin. These tumours comprise proliferations of both endothelial and pericytic cells. The association with Beckwith-Wiedemann syndrome may provide a clue to the molecular genetics of infantile haemangioma.