PT  - JOURNAL ARTICLE
AU  - Drut, R
AU  - Drut, R M
TI  - Angiocentric immunoproliferative lesion and angiocentric lymphoma of lymph node in children. A report of two cases
AID  - 10.1136/jcp.2004.022475
DP  - 2005 May 01
TA  - Journal of Clinical Pathology
PG  - 550--552
VI  - 58
IP  - 5
4099  - http://jcp.bmj.com/content/58/5/550.short
4100  - http://jcp.bmj.com/content/58/5/550.full
SO  - J Clin Pathol2005 May 01; 58
AB  - Aim: To report two examples of an angiocentric immunoproliferative lesion (AIL) and angiocentric angiodestructive lymphoma (AL) presenting in lymph nodes in children. Most commonly involving extranodal sites, AIL/AL rarely presents in the spleen and lymph nodes. Methods/Results: Case 1 presented as a cervical lymphadenopathy in a 3 year old girl being treated for pre-B cell acute lymphoblastic leukaemia. Histological and immunohistochemistry studies revealed an Epstein-Barr virus positive (EBV+), large B cell (CD20 and CD30+) AIL with large areas of necrosis, the whole resembling lymphomatoid granulomatosis. Case 2 presented as a large supraclavicular lymphadenopathy in a 13 year old boy. Histology and immunohistochemistry revealed an EBV–, large T cell (CD45RO, CD56, and CD30+) AL, presenting the features of so called angiocentric T cell/natural killer cell lymphoma, nasal type. Conclusions: The term AIL/AL refers to a heterogeneous group of conditions not unique to a particular type of lymphoid cell. These lesions are easily recognised by the histopathologist because of their extremely unusual angiocentric pattern. Although rare, AIL/AL may present as nodal lesions in children ab initio.