RT Journal Article
SR Electronic
T1 Three coexisting lymphomas in one patient: genetically related or only a coincidence?
JF Journal of Clinical Pathology
JO J Clin Pathol
FD BMJ Publishing Group Ltd and Association of Clinical Pathologists
SP 1312
OP 1315
DO 10.1136/jcp.2005.030825
VO 59
IS 12
A1 Steinhoff, M
A1 Assaf, C
A1 Anagnostopoulos, I
A1 Geilen, C C
A1 Stein, H
A1 Hummel, M
YR 2006
UL http://jcp.bmj.com/content/59/12/1312.abstract
AB The simultaneous manifestation of different lymphomas in the same patient or even in the same tissue, defined as composite lymphoma, is very rare. The exceptional case of a patient who, presented with simultaneous manifestation of three different lymphomas after 30 years of successful treatment of a nodal T cell lymphoma is reported here. The three lymphomas were: (1) primary cutaneous marginal zone B cell lymphoma (MZBL); (2) nodal Epstein–Barr virus (EBV)-associated classic Hodgkin’s lymphoma (cHL) of the B cell type; and (3) peripheral T cell lymphoma coexisting in the skin and cervical lymph node. Immunohistochemical and molecular analyses showed different clonal origins of EBV-negative cutaneous MZBL and EBV-positive B cell cHL and, in addition, the presence of the same clonal T cell population in the skin and lymph node. The simultaneous occurrence of three different, clonally unrelated lymphomas in one patient at the same time has not been reported yet.