RT Journal Article
SR Electronic
T1 Expression of calcitonin receptor-like receptor in human vascular tumours
JF Journal of Clinical Pathology
JO J Clin Pathol
FD BMJ Publishing Group Ltd and Association of Clinical Pathologists
SP 1104
OP 1107
DO 10.1136/jcp.2005.026930
VO 59
IS 10
A1 Hagner, S
A1 Stahl, U
A1 Grimm, T
A1 Stürzl, M
A1 Lang, R E
YR 2006
UL http://jcp.bmj.com/content/59/10/1104.abstract
AB Background: Vascular tumours such as Kaposi’s sarcoma and capillary haemangioma are characterised by abnormal vascularisation and proliferation of endothelial cells or neoplastic cells. Adrenomedullin, a potent vasodilative peptide, and its receptor, calcitonin receptor-like receptor (CRLR), play an important part in angiogenesis. Aim: To establish whether this system also plays a part in vascular diseases, showing abnormal proliferation such as vascular tumours. Methods: CRLR expression was investigated in several specimens of Kaposi’s sarcoma and other vascular tumours, using immunohistochemical analysis with a previously described CRLR-specific polyclonal antibody and reverse transcriptase-polymerase chain reaction. Results: Intense and specific CRLR-immunoreactive staining of neoplastic cells was observed in all specimens, which was of greater intensity than similar staining of adjacent normal endothelium. Conclusions: CRLR is expressed in vascular tumours and, with adrenomedullin, may have a role in neoplastic vascular growth.