RT Journal Article
SR Electronic
T1 The significance of substance P in physiological and malignant haematopoiesis
JF Journal of Clinical Pathology
JO J Clin Pathol
FD BMJ Publishing Group Ltd and Association of Clinical Pathologists
SP 749
OP 755
DO 10.1136/jcp.2006.041475
VO 60
IS 7
A1 Nowicki, Michal
A1 Ostalska-Nowicka, Danuta
A1 Kondraciuk, Beata
A1 Miskowiak, Bogdan
YR 2007
UL http://jcp.bmj.com/content/60/7/749.abstract
AB The role of substance P (SP) in physiological haematopoiesis is well established. However, it also seems to be important in the neoplastic transformation of bone marrow, leading to the development of acute leukaemia in children, and also metastases to bone marrow of solid tumours (particularly neuroblastoma and breast cancer) in early stages of these diseases. This review summarises the available data on SP involvement in both processes. In the future, SP antagonists may be used as anti-neoplastic drugs, for example by direct or indirect blocking of tumour cell proliferation through inhibition of growth factor production and interleukin-1b synthesis.