PT  - JOURNAL ARTICLE
AU  - Wong, N K S
AU  - Ng, F Y
AU  - Leung, G
TI  - Cytological distinction between high-risk and low-risk human papillomavirus infections in SurePath liquid-based cell preparations
AID  - 10.1136/jcp.2008.059881
DP  - 2008 Dec 01
TA  - Journal of Clinical Pathology
PG  - 1317--1322
VI  - 61
IP  - 12
4099  - http://jcp.bmj.com/content/61/12/1317.short
4100  - http://jcp.bmj.com/content/61/12/1317.full
SO  - J Clin Pathol2008 Dec 01; 61
AB  - Aims: To investigate the correlation of various diagnostic cytological features in SurePath liquid-based cell preparations with high-risk human papillomavirus (HPV) infection.Methods: Case–control study. SurePath specimens from 510 cases that had been tested for HPV DNA by Hybrid Capture 2 assay were retrieved and re-examined for 10 cytological features. Distribution of these features in high- and low-risk HPV types was compared and risk statistics were estimated. Effects of cervicitis on the manifestation of HPV cytological changes were adjusted by means of logistic regression.Results: Cytological features of nuclear hyperchromasia, multinucleation and atypical metaplastic cells were predominantly noted in high-risk HPV infection in the category of atypical squamous cells of undetermined significance/low-grade squamous intraepithelial lesion. The odds ratios of these three features were 6–12 times higher in high-risk than low-risk HPV infection.Conclusions: Some diagnostic cytological features can be used as markers in Pap smear screening for assessing the types of HPV infection.