RT Journal Article
SR Electronic
T1 Adiaspiromycosis mimicking widespread malignancy in a patient with pulmonary adenocarcinoma
JF Journal of Clinical Pathology
JO J Clin Pathol
FD BMJ Publishing Group Ltd and Association of Clinical Pathologists
SP 837
OP 839
DO 10.1136/jcp.2008.058107
VO 62
IS 9
A1 Denson, J L
A1 Keen, C E
A1 Froeschle, P O
A1 Toy, E W
A1 Borman, A M
YR 2009
UL http://jcp.bmj.com/content/62/9/837.abstract
AB Adiaspiromycosis, a mycotic disease of small animals, has rarely been reported in humans. The principle causative organism in Europe is Emmonsia crescens. Inhaled, dust-borne spores of E crescens fail to germinate in host tissue, instead increasing in size dramatically to become thick-walled, round adiapsores, which induce a granulomatous response. The pathological effects depend on the spore burden and host immunocompetence, and range from asymptomatic infection through to necrogranulomatous pneumonia, respiratory failure and, rarely, death. Diagnosis is principally made through histological examination. This report describes a case of a patient with low-grade, localised pulmonary adenocarcinoma with occult adiaspiromycosis that radiologically mimicked widespread malignancy. It is believed to be the first reported human case of adiaspiromycosis in the UK.