RT Journal Article SR Electronic T1 My approach to cardiothoracic transplantation and the role of the histocompatibility and immunogenetics laboratory in a rapidly developing field JF Journal of Clinical Pathology JO J Clin Pathol FD BMJ Publishing Group Ltd and Association of Clinical Pathologists SP 189 OP 193 DO 10.1136/jcp.2009.068478 VO 63 IS 3 A1 Carter, Vaughan YR 2010 UL http://jcp.bmj.com/content/63/3/189.abstract AB Cardiothoracic transplantation presents specific challenges. The lack of long-term replacement therapy (such as dialysis for kidney patients) creates a more urgent situation than for other forms of transplantation, necessitating a different approach. This review looks at ways in which the challenges are being met and the integral role of the histocompatibility and immunogenetics laboratory.