RT Journal Article
SR Electronic
T1 Alterations in glycosylation as biomarkers for cancer detection
JF Journal of Clinical Pathology
JO J Clin Pathol
FD BMJ Publishing Group Ltd and Association of Clinical Pathologists
SP 322
OP 329
DO 10.1136/jcp.2009.071035
VO 63
IS 4
A1 Reis, Celso A
A1 Osorio, Hugo
A1 Silva, Luisa
A1 Gomes, Catarina
A1 David, Leonor
YR 2010
UL http://jcp.bmj.com/content/63/4/322.abstract
AB Glycoconjugates constitute a major class of biomolecules which include glycoproteins, glycosphingolipids and proteoglycans. Glycans are involved in several physiological and pathological conditions, such as host–pathogen interactions, cell differentiation, migration, tumour invasion and metastisation, cell trafficking and signalling. Cancer is associated with glycosylation alterations in glycoproteins and glycolipids. This review describes various aspects of protein glycosylation with the focus on alterations associated with human cancer. The application of these glycosylation modifications as biomarkers for cancer detection in tumour tissues and serological assays is summarised.