PT  - JOURNAL ARTICLE
AU  - Clarke, Blaise A
AU  - Gilks, C Blake
TI  - Endometrial carcinoma: controversies in histopathological assessment of grade and tumour cell type
AID  - 10.1136/jcp.2009.071225
DP  - 2010 May 01
TA  - Journal of Clinical Pathology
PG  - 410--415
VI  - 63
IP  - 5
4099  - http://jcp.bmj.com/content/63/5/410.short
4100  - http://jcp.bmj.com/content/63/5/410.full
SO  - J Clin Pathol2010 May 01; 63
AB  - Histopathological assessment of tumour grade and cell type is central to the management of endometrial carcinoma, guiding the extent of surgery and the use of adjuvant radiation therapy and chemotherapy. Endometrioid carcinomas are usually low grade but high-grade examples are encountered, and they have a significantly worse prognosis, similar to that of high-grade subtypes such as serous and clear cell carcinoma. This article reviews the various grading systems that have been proposed for use with endometrioid endometrial carcinoma, and discusses the recent progress in cell type assignment, including the use of immunohistochemistry as a diagnostic adjunct.