RT Journal Article
SR Electronic
T1 Endometrial carcinoma: controversies in histopathological assessment of grade and tumour cell type
JF Journal of Clinical Pathology
JO J Clin Pathol
FD BMJ Publishing Group Ltd and Association of Clinical Pathologists
SP 410
OP 415
DO 10.1136/jcp.2009.071225
VO 63
IS 5
A1 Clarke, Blaise A
A1 Gilks, C Blake
YR 2010
UL http://jcp.bmj.com/content/63/5/410.abstract
AB Histopathological assessment of tumour grade and cell type is central to the management of endometrial carcinoma, guiding the extent of surgery and the use of adjuvant radiation therapy and chemotherapy. Endometrioid carcinomas are usually low grade but high-grade examples are encountered, and they have a significantly worse prognosis, similar to that of high-grade subtypes such as serous and clear cell carcinoma. This article reviews the various grading systems that have been proposed for use with endometrioid endometrial carcinoma, and discusses the recent progress in cell type assignment, including the use of immunohistochemistry as a diagnostic adjunct.