PT  - JOURNAL ARTICLE
AU  - Ryan, Paul
AU  - Finelli, Antonio
AU  - Lawrentschuk, Nathan
AU  - Fleshner, Neil
AU  - Sweet, Joan
AU  - Cheung, Carol
AU  - van der Kwast, Theodorus
AU  - Evans, Andrew
TI  - Prostatic needle biopsies following primary high intensity focused ultrasound (HIFU) therapy for prostatic adenocarcinoma: histopathological features in tumour and non-tumour tissue
AID  - 10.1136/jclinpath-2011-200460
DP  - 2012 Aug 01
TA  - Journal of Clinical Pathology
PG  - 729--734
VI  - 65
IP  - 8
4099  - http://jcp.bmj.com/content/65/8/729.short
4100  - http://jcp.bmj.com/content/65/8/729.full
SO  - J Clin Pathol2012 Aug 01; 65
AB  - Aims High intensity focused ultrasound (HIFU) is currently offered as primary treatment for patients with clinically localised prostate cancer. Data on histopathological features of post-treatment biopsies are limited. Methods Pretreatment biopsies were identified in 45 men (age range 41–85) who received primary HIFU therapy. Post-HIFU biopsies were performed in 30 of these patients (67%) at mean 14.1 months (95% CI 11.7 to 16.5) follow-up, 22 due to rising PSA and eight as part of routine follow-up. Biopsies were examined for presence, distribution and extent of adenocarcinoma, Gleason scores, use of standard immunohistochemistry and ablative tissue changes were attributable to HIFU. Results In post-HIFU biopsies performed for biochemical failure, 17/22 (77%) contained adenocarcinoma; 4/22 (18%) had higher post-HIFU Gleason score; 3/22 (14%) had newly recognised bilateral involvement; and 4/22 (18%) had higher percentage tissue involvement compared with pre-HIFU biopsies. Of cases without rising post-HIFU PSA, 2/8 (25%) routine follow-up biopsies contained adenocarcinoma. Stromal fibrosis was the commonest finding in non-tumour post-HIFU biopsy tissue (17/30, 57%) with coagulative necrosis occurring in fewer cases (4/30, 13%) and over a shorter follow-up interval than cases showing fibrosis (8.5 (0.2–16.8) vs 15.3 (11.5–19.1) months). Treatment effects in tumour cells precluding the assignment of Gleason scores or use of immunohistochemistry in post-HIFU biopsies were not identified. Conclusion Post-HIFU biopsies are positive in more than 75% of patients with elevated or rising PSA. Stromal fibrosis is common but the tissue effects of this modality do not appear to impair pathologists' ability to detect and grade adenocarcinoma in follow-up biopsies.