PT  - JOURNAL ARTICLE
AU  - Augello, Claudia
AU  - Gianelli, Umberto
AU  - Savi, Federica
AU  - Moro, Alessia
AU  - Bonoldi, Emanuela
AU  - Gambacorta, Marcello
AU  - Vaira, Valentina
AU  - Baldini, Luca
AU  - Bosari, Silvano
TI  - MicroRNA as potential biomarker in HCV-associated diffuse large B-cell lymphoma
AID  - 10.1136/jclinpath-2014-202352
DP  - 2014 Aug 01
TA  - Journal of Clinical Pathology
PG  - 697--701
VI  - 67
IP  - 8
4099  - http://jcp.bmj.com/content/67/8/697.short
4100  - http://jcp.bmj.com/content/67/8/697.full
SO  - J Clin Pathol2014 Aug 01; 67
AB  - Aims To identify molecular characteristics to hepatitis C virus (HCV)-associated diffuse large B-cell lymphoma (DLBCL) through a comprehensive miRNAs expression profiling. Methods In this study, miRNA profiles were obtained from 37 patients with DLBCLs and 60 patients with reactive lymph nodes, equally distributed according to HCV presence. Germinal centres, from reactive lymph nodes were used as controls. Clinical features at presentation were available for all patients. Results A set of 52 miRNAs define a signature for HCV-associated DLBCL. Importantly, decreased expression of miR-138-5p and increased expression of miR-147a, miR-147b and miR-511-5p in HCV DLBCL was found to be a poor prognostic factor for HCV-positive DLBCL patients. Conclusions These data reveal molecular differences in diffuse DLBCL patients according to HCV presence, potentially useful as novel prognostic or therapeutic biomarkers.