PT  - JOURNAL ARTICLE
AU  - Sidiropoulos, Konstantinos G
AU  - Martinez-Escala, M Estela
AU  - Yelamos, Oriol
AU  - Guitart, Joan
AU  - Sidiropoulos, Michael
TI  - Primary cutaneous T-cell lymphomas: a review
AID  - 10.1136/jclinpath-2015-203133
DP  - 2015 Dec 01
TA  - Journal of Clinical Pathology
PG  - 1003--1010
VI  - 68
IP  - 12
4099  - http://jcp.bmj.com/content/68/12/1003.short
4100  - http://jcp.bmj.com/content/68/12/1003.full
SO  - J Clin Pathol2015 Dec 01; 68
AB  - Primary cutaneous T-cell lymphomas (CTCLs) represent a number of extranodal lymphomas arising from a malignant population of lymphocytes in the skin, with the most common type being mycosis fungoides (MF) representing half of all primary CTCLs. Despite advances in immunohistochemistry and molecular methodology, significant diagnostic challenges remain due to phenotypic overlap of primary CTCLs with several inflammatory dermatoses, secondary lymphomas, among other conditions. Clinical features such as presentation and morphology, staging, histology, immunophenotype and molecular features must be considered in detail before a diagnosis is made in order to minimise false-positive, false-negative and indeterminate diagnoses. Herein, we review primary CTCLs, including epidemiological data, a brief summary of clinical presentations, immunophenotype, molecular signatures and differential diagnoses.