RT Journal Article
SR Electronic
T1 Primary cutaneous T-cell lymphomas: a review
JF Journal of Clinical Pathology
JO J Clin Pathol
FD BMJ Publishing Group Ltd and Association of Clinical Pathologists
SP 1003
OP 1010
DO 10.1136/jclinpath-2015-203133
VO 68
IS 12
A1 Sidiropoulos, Konstantinos G
A1 Martinez-Escala, M Estela
A1 Yelamos, Oriol
A1 Guitart, Joan
A1 Sidiropoulos, Michael
YR 2015
UL http://jcp.bmj.com/content/68/12/1003.abstract
AB Primary cutaneous T-cell lymphomas (CTCLs) represent a number of extranodal lymphomas arising from a malignant population of lymphocytes in the skin, with the most common type being mycosis fungoides (MF) representing half of all primary CTCLs. Despite advances in immunohistochemistry and molecular methodology, significant diagnostic challenges remain due to phenotypic overlap of primary CTCLs with several inflammatory dermatoses, secondary lymphomas, among other conditions. Clinical features such as presentation and morphology, staging, histology, immunophenotype and molecular features must be considered in detail before a diagnosis is made in order to minimise false-positive, false-negative and indeterminate diagnoses. Herein, we review primary CTCLs, including epidemiological data, a brief summary of clinical presentations, immunophenotype, molecular signatures and differential diagnoses.