PT  - JOURNAL ARTICLE
AU  - Woodward, Wendy A
AU  - Sneige, Nour
AU  - Winter, Kathryn
AU  - Kuerer, Henry Mark
AU  - Hudis, Clifford
AU  - Rakovitch, Eileen
AU  - Smith, Barbara L
AU  - Pierce, Lori J
AU  - Germano, Isabelle
AU  - Pu, Anthony T
AU  - Walker, Eleanor M
AU  - Grisell, David Lawrence
AU  - White, Julia R
AU  - McCormick, Beryl
TI  - Web based pathology assessment in RTOG 98-04
AID  - 10.1136/jclinpath-2014-202370
DP  - 2014 Sep 01
TA  - Journal of Clinical Pathology
PG  - 777--780
VI  - 67
IP  - 9
4099  - http://jcp.bmj.com/content/67/9/777.short
4100  - http://jcp.bmj.com/content/67/9/777.full
SO  - J Clin Pathol2014 Sep 01; 67
AB  - Aims Radiation Therapy Oncology Group 98-04 sought to identify women with ‘good risk’ ductal carcinoma in situ (DCIS) who receive no significant benefit from radiation. Enrolment criteria excluded close or positive margins and grade 3 disease. To ensure reproducibility in identifying good risk pathology, an optional web based teaching tool was developed and a random sampling of 10% of submitted slides were reviewed by a central pathologist. Methods Submitting pathologists were asked to use the web based teaching tool and submit an assessment of the tool along with the pathology specimen form and DCIS H&E stained slide. Per protocol pathology was centrally reviewed for 10% of the cases. Results Of the 55 DCIS cases reviewed, three had close or positive margins and three were assessed to include grade 3 DCIS, therefore 95% of DCIS cases reviewed were correctly graded, and 89% reviewed were pathologically appropriate for enrolment. Regarding the teaching tool, 13% of DCIS cases included forms that indicated the website was used. One of these seven who used the website submitted DCIS of grade 3. Conclusions Central review demonstrates high pathological concordance with enrolment eligibility, particularly with regard to accurate grading. The teaching tool appeared to be underused.