RT Journal Article
SR Electronic
T1 Web based pathology assessment in RTOG 98-04
JF Journal of Clinical Pathology
JO J Clin Pathol
FD BMJ Publishing Group Ltd and Association of Clinical Pathologists
SP 777
OP 780
DO 10.1136/jclinpath-2014-202370
VO 67
IS 9
A1 Woodward, Wendy A
A1 Sneige, Nour
A1 Winter, Kathryn
A1 Kuerer, Henry Mark
A1 Hudis, Clifford
A1 Rakovitch, Eileen
A1 Smith, Barbara L
A1 Pierce, Lori J
A1 Germano, Isabelle
A1 Pu, Anthony T
A1 Walker, Eleanor M
A1 Grisell, David Lawrence
A1 White, Julia R
A1 McCormick, Beryl
YR 2014
UL http://jcp.bmj.com/content/67/9/777.abstract
AB Aims Radiation Therapy Oncology Group 98-04 sought to identify women with ‘good risk’ ductal carcinoma in situ (DCIS) who receive no significant benefit from radiation. Enrolment criteria excluded close or positive margins and grade 3 disease. To ensure reproducibility in identifying good risk pathology, an optional web based teaching tool was developed and a random sampling of 10% of submitted slides were reviewed by a central pathologist. Methods Submitting pathologists were asked to use the web based teaching tool and submit an assessment of the tool along with the pathology specimen form and DCIS H&E stained slide. Per protocol pathology was centrally reviewed for 10% of the cases. Results Of the 55 DCIS cases reviewed, three had close or positive margins and three were assessed to include grade 3 DCIS, therefore 95% of DCIS cases reviewed were correctly graded, and 89% reviewed were pathologically appropriate for enrolment. Regarding the teaching tool, 13% of DCIS cases included forms that indicated the website was used. One of these seven who used the website submitted DCIS of grade 3. Conclusions Central review demonstrates high pathological concordance with enrolment eligibility, particularly with regard to accurate grading. The teaching tool appeared to be underused.