RT Journal Article
SR Electronic
T1 The clinical significance of fibrinogen plasma levels in patients with diffuse large B cell lymphoma
JF Journal of Clinical Pathology
JO J Clin Pathol
FD BMJ Publishing Group Ltd and Association of Clinical Pathologists
SP 326
OP 330
DO 10.1136/jclinpath-2015-203356
VO 69
IS 4
A1 Troppan, Katharina T
A1 Melchardt, Thomas
A1 Wenzl, Kerstin
A1 Schlick, Konstantin
A1 Deutsch, Alexander
A1 Bullock, Marc D
A1 Reitz, Daniel
A1 Beham-Schmid, Christine
A1 Weiss, Lukas
A1 Neureiter, Daniel
A1 Tränkenschuh, Wolfgang
A1 Greil, Richard
A1 Neumeister, Peter
A1 Egle, Alexander
A1 Pichler, Martin
YR 2016
UL http://jcp.bmj.com/content/69/4/326.abstract
AB Background Fibrinogen plays a crucial role in the pathophysiology of tumour cell growth, invasion and metastasis. The aim of this study was to evaluate the prognostic significance of pretreatment plasma fibrinogen levels in patients with diffuse large B cell lymphoma (DLBCL)Methods Data from 372 patients with DLBCL, diagnosed and treated between 2004 and 2013 at two Austrian centres, were evaluated retrospectively. The prognostic influences of plasma fibrinogen levels and other factors, including age, tumour stage and the National Comprehensive Cancer Network-International Prognostic Index, on 5-year overall survival (OS) and 5-year disease-free survival (DFS) were studied using Kaplan–Meier curves as well as univariate and multivariate Cox regression models.Results Kaplan–Meier analysis revealed that a high fibrinogen plasma level is associated with decreased 5-year OS and 5-year DFS in patients with DLBCL (p<0.001, log-rank test). Furthermore, in multivariate analysis, elevated serum fibrinogen was found to be an independent marker of poor clinical outcome: 5-year OS (HR=1.69, 95% CI 1.06 to 2.72, p=0.029) and 5-year DFS (HR=1.68, 95% CI 1.08 to 2.61, p=0.021).Conclusions In the current study, we demonstrate that high plasma fibrinogen levels at diagnosis predict poor outcome in patients with DLBCL.Trial registration number 25-434 ex 12713 and 415-EP/73/127-2012.