PT  - JOURNAL ARTICLE
AU  - Vera-Badillo, Francisco E
AU  - Chang, Martin C
AU  - Kuruzar, Gordana
AU  - Ocana, Alberto
AU  - Templeton, Arnoud J
AU  - Seruga, Bostjan
AU  - Goldstein, Robyn
AU  - Bedard, Philippe L
AU  - Tannock, Ian F
AU  - Amir, Eitan
TI  - Association between androgen receptor expression, Ki-67 and the 21-gene recurrence score in non-metastatic, lymph node-negative, estrogen receptor-positive and HER2-negative breast cancer
AID  - 10.1136/jclinpath-2015-203012
DP  - 2015 Oct 01
TA  - Journal of Clinical Pathology
PG  - 839--843
VI  - 68
IP  - 10
4099  - http://jcp.bmj.com/content/68/10/839.short
4100  - http://jcp.bmj.com/content/68/10/839.full
SO  - J Clin Pathol2015 Oct 01; 68
AB  - Background The mechanisms underlying the favourable prognosis of androgen receptor (AR) expression in breast cancer are unknown.Methods The associations between the 21-gene recurrence score (RS), AR, grade, mitotic score, Ki-67 and estrogen receptor (ER) and progesterone receptor (PgR) expression were explored in sequential women with lymph node-negative, ER-positive and HER2-negative breast cancer. Statistical significance of this exploratory study was defined as p<0.10.Results Analysis comprised 70 women. Most tumours had high AR expression (97% had scores >3). Median RS was 15 (range 1–53). AR expression showed a minimally significant positive correlation with ER (R=0.37), but no correlation with Ki-67 (R=−0.18). In univariable analysis, AR (p=0.01), ER (p<0.001) and PgR (p<0.001) had significant negative associations with RS. Ki-67 (p=0.16), grade (p=0.40) and mitotic score (p=0.23) showed no association with RS. Multivariable analysis showed similar associations.Conclusions AR is associated with lower RS, but not with Ki-67.