RT Journal Article
SR Electronic
T1 Association between androgen receptor expression, Ki-67 and the 21-gene recurrence score in non-metastatic, lymph node-negative, estrogen receptor-positive and HER2-negative breast cancer
JF Journal of Clinical Pathology
JO J Clin Pathol
FD BMJ Publishing Group Ltd and Association of Clinical Pathologists
SP 839
OP 843
DO 10.1136/jclinpath-2015-203012
VO 68
IS 10
A1 Vera-Badillo, Francisco E
A1 Chang, Martin C
A1 Kuruzar, Gordana
A1 Ocana, Alberto
A1 Templeton, Arnoud J
A1 Seruga, Bostjan
A1 Goldstein, Robyn
A1 Bedard, Philippe L
A1 Tannock, Ian F
A1 Amir, Eitan
YR 2015
UL http://jcp.bmj.com/content/68/10/839.abstract
AB Background The mechanisms underlying the favourable prognosis of androgen receptor (AR) expression in breast cancer are unknown.Methods The associations between the 21-gene recurrence score (RS), AR, grade, mitotic score, Ki-67 and estrogen receptor (ER) and progesterone receptor (PgR) expression were explored in sequential women with lymph node-negative, ER-positive and HER2-negative breast cancer. Statistical significance of this exploratory study was defined as p<0.10.Results Analysis comprised 70 women. Most tumours had high AR expression (97% had scores >3). Median RS was 15 (range 1–53). AR expression showed a minimally significant positive correlation with ER (R=0.37), but no correlation with Ki-67 (R=−0.18). In univariable analysis, AR (p=0.01), ER (p<0.001) and PgR (p<0.001) had significant negative associations with RS. Ki-67 (p=0.16), grade (p=0.40) and mitotic score (p=0.23) showed no association with RS. Multivariable analysis showed similar associations.Conclusions AR is associated with lower RS, but not with Ki-67.