PT  - JOURNAL ARTICLE
AU  - Kalimuthu, Sangeetha N
AU  - Serra, Stefano
AU  - Dhani, Neesha
AU  - Chetty, Runjan
TI  - The spectrum of histopathological changes encountered in pancreatectomy specimens after neoadjuvant chemoradiation, including subtle and less-well-recognised changes
AID  - 10.1136/jclinpath-2016-203604
DP  - 2016 Jun 01
TA  - Journal of Clinical Pathology
PG  - 463--471
VI  - 69
IP  - 6
4099  - http://jcp.bmj.com/content/69/6/463.short
4100  - http://jcp.bmj.com/content/69/6/463.full
SO  - J Clin Pathol2016 Jun 01; 69
AB  - Preoperative (neoadjuvant) chemoradiation therapy/treatment (NCRT) is emerging as an important treatment modality in borderline resectable pancreatic ductal adenocarcinoma (PDAC). The constellation of histopathological changes secondary to chemoradiation is diverse and has been well documented, particularly in other gastrointestinal organs such as the oesophagus and colorectum. However, the histological changes specific to the pancreas have not been fully characterised and described. This review aims to provide a detailed catalogue of histological features associated with NCRT-treated PDAC and highlight any subtle, less-recognised changes.