RT Journal Article
SR Electronic
T1 The spectrum of histopathological changes encountered in pancreatectomy specimens after neoadjuvant chemoradiation, including subtle and less-well-recognised changes
JF Journal of Clinical Pathology
JO J Clin Pathol
FD BMJ Publishing Group Ltd and Association of Clinical Pathologists
SP 463
OP 471
DO 10.1136/jclinpath-2016-203604
VO 69
IS 6
A1 Kalimuthu, Sangeetha N
A1 Serra, Stefano
A1 Dhani, Neesha
A1 Chetty, Runjan
YR 2016
UL http://jcp.bmj.com/content/69/6/463.abstract
AB Preoperative (neoadjuvant) chemoradiation therapy/treatment (NCRT) is emerging as an important treatment modality in borderline resectable pancreatic ductal adenocarcinoma (PDAC). The constellation of histopathological changes secondary to chemoradiation is diverse and has been well documented, particularly in other gastrointestinal organs such as the oesophagus and colorectum. However, the histological changes specific to the pancreas have not been fully characterised and described. This review aims to provide a detailed catalogue of histological features associated with NCRT-treated PDAC and highlight any subtle, less-recognised changes.