RT Journal Article
SR Electronic
T1 Intraductal carcinoma of prostate reporting practice: a survey of expert European uropathologists
JF Journal of Clinical Pathology
JO J Clin Pathol
FD BMJ Publishing Group Ltd and Association of Clinical Pathologists
SP 852
OP 857
DO 10.1136/jclinpath-2016-203658
VO 69
IS 10
A1 Varma, Murali
A1 Egevad, Lars
A1 Algaba, Ferran
A1 Berney, Daniel
A1 Bubendorf, Lukas
A1 Camparo, Philippe
A1 Comperat, Eva
A1 Erbersdobler, Andreas
A1 Griffiths, David
A1 Grobholz, Rainer
A1 Haitel, Andrea
A1 Hulsbergen-van de Kaa, Christina
A1 Langner, Cord
A1 Loftus, Barbara
A1 Lopez-Beltran, Antonio
A1 Mayer, Nick
A1 Nesi, Gabriella
A1 Oliveira, Pedro
A1 Oxley, Jon
A1 Rioux-Leclercq, Nathalie
A1 Seitz, Gerhard
A1 Shanks, Jonathan
A1 Kristiansen, Glen
YR 2016
UL http://jcp.bmj.com/content/69/10/852.abstract
AB Background It is unclear whether the reported variation in the diagnosis of intraductal carcinoma of the prostate (IDC-P) is due to variable interpretation of borderline morphology, use of different diagnostic criteria or both.Aims We sought to determine the degree of variation in the diagnostic criteria and reporting rules for IDC-P in prostate biopsies employed by expert uropathologists.Methods A questionnaire survey was circulated to 23 expert uropathologists from 11 European countries.Results Criteria used for diagnosis of IDC-P included solid intraductal growth (100%), dense cribriform (96%), loose cribriform/micropapillary with nuclear size >6× normal (83%) or comedonecrosis (74%) and dilated ducts >2× normal (39%). ‘Nuclear size’ was interpreted as nuclear area by 74% and nuclear diameter by 21%. Pure IDC-P in needle biopsies was reported by 100% and Gleason graded by 30%. All would perform immunohistochemistry in such cases to rule out invasive cancer. An IDC-P component associated with invasive cancer would be included in the determination of tumour extent and number of cores involved by 74% and 83%, respectively. 52% would include IDC-P component when grading invasive cancer. 48% would perform immunohistochemistry in solid or cribriform nests with comedonecrosis to exclude IDC-P (17% routinely, 30% if the focus appeared to have basal cells on H&E). 48% graded such foci as Gleason pattern 5 even if immunohistochemistry demonstrated the presence of basal cells.Conclusions There is a need for more clarity in the definition of some of the diagnostic criteria for IDC-P as well as for greater standardisation of IDC-P reporting.