PT  - JOURNAL ARTICLE
AU  - Co, Michael
AU  - Chen, Clement
AU  - Tsang, Julia Y
AU  - Tse, Gary
AU  - Kwong, Ava
TI  - Mammary phyllodes tumour: a 15-year multicentre clinical review
AID  - 10.1136/jclinpath-2017-204827
DP  - 2018 Jun 01
TA  - Journal of Clinical Pathology
PG  - 493--497
VI  - 71
IP  - 6
4099  - http://jcp.bmj.com/content/71/6/493.short
4100  - http://jcp.bmj.com/content/71/6/493.full
SO  - J Clin Pathol2018 Jun 01; 71
AB  - Aims Phyllodes tumour (PT) is an uncommon fibroepithelial tumour of the breast. It has a spectrum of aggressiveness in biological behaviour with chance of local recurrence and, occasionally, metastasis.Methods A 15-year retrospective review from a multicentre database in Hong Kong was performed.Results Clinical and pathological records of 465 patients with 469 PTs between 1998 and 2014 were reviewed. Median age of occurrence was 44 years (range 12–86 years). 281 (59.9%) PTs were benign, 124 (26.4%) were borderline and 64 (13.6%) were malignant. About half of all PTs (239, 51.5%) were between 2 and 5 cm while another 186 (40.1%) were >5 cm in size. Most PT (84.6%) were radiologically benign. Breast-conserving surgery (BCS) was feasible in 384 (82%) patients, whereas 84 (18%) patients had mastectomy. Multivariate analysis found that positive surgical margin (P<0.001) and BCS (P<0.001) were the only significant risk factors for local recurrence, while large tumour size (P=0.008) and malignant PT histotype (P<0.001) were the only significant risk factors for metastasis. Long-term prognosis of benign and borderline PT was excellent. After median follow-up interval of 85 months (range 12–180 months), the disease-specific survival of benign, borderline and malignant PT were 99.6%, 100% and 90.6%, respectively.Conclusions Local recurrence of PTs occurs irrespective of the tumour grade. Surgical margin is the only amendable factor to reduce the chance of recurrence.