PT  - JOURNAL ARTICLE
AU  - Fung, Angela W.S.
AU  - Sugumar, Vijithan
AU  - Ren, Annie He
AU  - Kulasingam, Vathany
TI  - Emerging role of clinical mass spectrometry in pathology
AID  - 10.1136/jclinpath-2019-206269
DP  - 2020 Feb 01
TA  - Journal of Clinical Pathology
PG  - 61--69
VI  - 73
IP  - 2
4099  - http://jcp.bmj.com/content/73/2/61.short
4100  - http://jcp.bmj.com/content/73/2/61.full
SO  - J Clin Pathol2020 Feb 01; 73
AB  - Mass spectrometry-based assays have been increasingly implemented in various disciplines in clinical diagnostic laboratories for their combined advantages in multiplexing capacity and high analytical specificity and sensitivity. It is now routinely used in areas including reference methods development, therapeutic drug monitoring, toxicology, endocrinology, paediatrics, immunology and microbiology to identify and quantify biomolecules in a variety of biological specimens. As new ionisation methods, instrumentation and techniques are continuously being improved and developed, novel mass spectrometry-based clinical applications will emerge for areas such as proteomics, metabolomics, haematology and anatomical pathology. This review will summarise the general principles of mass spectrometry and specifically highlight current and future clinical applications in anatomical pathology.