RT Journal Article
SR Electronic
T1 Emerging role of clinical mass spectrometry in pathology
JF Journal of Clinical Pathology
JO J Clin Pathol
FD BMJ Publishing Group Ltd and Association of Clinical Pathologists
SP 61
OP 69
DO 10.1136/jclinpath-2019-206269
VO 73
IS 2
A1 Fung, Angela W.S.
A1 Sugumar, Vijithan
A1 Ren, Annie He
A1 Kulasingam, Vathany
YR 2020
UL http://jcp.bmj.com/content/73/2/61.abstract
AB Mass spectrometry-based assays have been increasingly implemented in various disciplines in clinical diagnostic laboratories for their combined advantages in multiplexing capacity and high analytical specificity and sensitivity. It is now routinely used in areas including reference methods development, therapeutic drug monitoring, toxicology, endocrinology, paediatrics, immunology and microbiology to identify and quantify biomolecules in a variety of biological specimens. As new ionisation methods, instrumentation and techniques are continuously being improved and developed, novel mass spectrometry-based clinical applications will emerge for areas such as proteomics, metabolomics, haematology and anatomical pathology. This review will summarise the general principles of mass spectrometry and specifically highlight current and future clinical applications in anatomical pathology.