PT  - JOURNAL ARTICLE
AU  - Moyano Crespo, Gabriela Deisi
AU  - Cecenarro, Laura Anahí
AU  - Perez, Pablo
AU  - Guido, Carolina
AU  - Sosa, Liliana del Valle
AU  - Berhard, Celina
AU  - Aballay, Laura Rosana
AU  - Gutiérrez, Silvina
AU  - Petiti, Juan Pablo
AU  - Torres, Alicia
AU  - Mukdsi, Jorge
TI  - Association of PTP4A3 expression and tumour size in functioning pituitary adenoma: a descriptive study
AID  - 10.1136/jclinpath-2020-206728
DP  - 2021 Mar 01
TA  - Journal of Clinical Pathology
PG  - 190--193
VI  - 74
IP  - 3
4099  - http://jcp.bmj.com/content/74/3/190.short
4100  - http://jcp.bmj.com/content/74/3/190.full
SO  - J Clin Pathol2021 Mar 01; 74
AB  - Background PTP4A3 is a subclass of a protein tyrosine phosphatase super family and is expressed in a range of epithelial neoplasms. We evaluated PTP4A3 expression and its association with clinicopathological parameters in different types of functioning pituitary adenomas.Methods A total of 34 functioning pituitary adenomas samples were evaluated in this observational study. PTP4A3 expression was examined by immunohistochemical staining, and, possible correlations between PTP4A3 and some clinicopathological variables were investigated.Results PTP4A3 was expressed in 19 out of 34 tumours (55%), at the cytoplasmic level of tumorous cells. Moreover, there was significant association (p=0.042) between PTP4A3 expression and tumorous size.Conclusions PTP4A3 was expressed in more than half of the tumours analysed, with there being a significant association with the tumorous size of functioning adenomas. This allows to speculate that PTP4A3 may regulate tumour growth, although further investigations are necessary to determine if this phosphatase can serve as a biomarker or used as a therapeutic target in pituitary macroadenomas.