RT Journal Article
SR Electronic
T1 Fatal pulmonary fibrosis: a post-COVID-19 autopsy case
JF Journal of Clinical Pathology
JO J Clin Pathol
FD BMJ Publishing Group Ltd and Association of Clinical Pathologists
SP 400
OP 402
DO 10.1136/jclinpath-2020-206879
VO 74
IS 6
A1 Schwensen, Hanna Ferløv
A1 Borreschmidt, Line Kristine
A1 Storgaard, Merete
A1 Redsted, Søren
A1 Christensen, Steffen
A1 Madsen, Line Bille
YR 2021
UL http://jcp.bmj.com/content/74/6/400.abstract
AB There is growing evidence of histopathological changes in autopsied individuals infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); however, data on histopathological changes in autopsied patients with eradicated COVID-19 are limited. We performed an autopsy on a Caucasian female in her 80s, who died due to severe, bilateral pulmonary fibrosis after eliminated SARS-CoV-2 infection. In addition, CT scans from 2 months before infection and from 6 days prior to death were compared. Comparison of the CT scans showed bilateral development of widespread fibrosis in previously healthy lungs. Microscopic examination showed different areas with acute and organising diffuse alveolar damage and fibrosis with honeycomb-like remodelling and bronchial metaplasia. We here report a unique autopsy case with development of widespread pulmonary fibrosis in a woman in her 80s with previous COVID-19 and no history of pulmonary illnesses.