PT - JOURNAL ARTICLE AU - Porto, Luis Cristovao AU - Costa, Claudia H AU - Nunes, Alessandra S AU - Bouzas, Isabel AU - Ferreira, Tiago F AU - Porto, Vinicius M AU - Secco, Danielle A AU - Vilas Boas, Sandra AU - Faria, Anamelia Costa AU - Rufino, Rogerio ED - , TI - Clinical and laboratory characteristics in outpatient diagnosis of COVID-19 in healthcare professionals in Rio de Janeiro, Brazil AID - 10.1136/jclinpath-2020-206797 DP - 2022 Mar 01 TA - Journal of Clinical Pathology PG - 185--192 VI - 75 IP - 3 4099 - http://jcp.bmj.com/content/75/3/185.short 4100 - http://jcp.bmj.com/content/75/3/185.full SO - J Clin Pathol2022 Mar 01; 75 AB - Aims This study aimed to identify the symptoms associated with early stage SARS-CoV-2 (COVID-19) infections in healthcare professionals (HCPs) using both clinical and laboratory data.Methods A total of 1297 patients, admitted between 18 March and 8 April 2020, were stratified according to their risk of developing COVID-19 using their responses to a questionnaire designed to evaluate symptoms and risk conditions.Results Anosmia/hyposmia (p<0.0001), fever (p<0.0001), body pain (p<0.0001) and chills (p=0.001) were all independent predictors for COVID-19, with a 72% estimated probability for detecting COVID-19 in nasopharyngeal swab samples. Leucopenia, relative monocytosis, decreased eosinophil values, C reactive protein (CRP) and platelets were also shown to be significant independent predictors for COVID-19.Conclusions The significant clinical features for COVID-19 were identified as anosmia, fever, chills and body pain. Elevated CRP, leucocytes under 5400×109/L and relative monocytosis (>9%) were common among patients with a confirmed COVID-19 diagnosis. These variables may help, in the absence of reverse transcriptase PCR tests, to identify possible COVID-19 infections during pandemic outbreaks.Summary From 19 March to 8 April 2020, 1297 patients attended the Polyclinic Piquet Carneiro for COVID-19 detection. HCP data were analysed, and significant clinical features were anosmia, fever, chills and body pain. Elevated CRP, leucopenia and monocytosis were common in COVID-19.Data are available on reasonable request. All data relevant to the study are included in the article. Data are not in a repository. Signs and symptoms, comorbidities and laboratory results may be available in a deidentified participant data.