RT Journal Article
SR Electronic
T1 Identification of a protein expression signature distinguishing early from organising diffuse alveolar damage in COVID-19 patients
JF Journal of Clinical Pathology
JO J Clin Pathol
FD BMJ Publishing Group Ltd and Association of Clinical Pathologists
SP 561
OP 565
DO 10.1136/jcp-2023-208771
VO 76
IS 8
A1 Ashwin, Helen
A1 Milross, Luke
A1 Wilson, Julie
A1 Majo, Joaquim
A1 Hang Lee, Jimmy Tsz
A1 Calder, Grant
A1 Hunter, Bethany
A1 James, Sally
A1 Lagos, Dimitris
A1 Signoret, Nathalie
A1 Filby, Andrew
A1 Bayraktar, Omer Ali
A1 Fisher, Andrew J
A1 Kaye, Paul M
YR 2023
UL http://jcp.bmj.com/content/76/8/561.abstract
AB Diffuse alveolar damage (DAD) is the histological expression of acute respiratory distress syndrome and characterises lung pathology due to infection with SARS-CoV-2, and other respiratory pathogens of clinical significance. DAD reflects a time-dependent immunopathological process, progressing from an early/exudative stage through to an organising/fibrotic stage, yet within an individual these different stages of DAD may coexist. Understanding the progression of DAD is central to the development of new therapeutics to limit progressive lung damage. Here, we applied highly multiplexed spatial protein profiling to autopsy lung tissues derived from 27 patients who died from COVID-19 and identified a protein signature (ARG1, CD127, GZMB, IDO1, Ki67, phospho-PRAS40 (T246) and VISTA) that distinguishes early DAD from late DAD with good predictive accuracy. These proteins warrant further investigation as potential regulators of DAD progression.