PT  - JOURNAL ARTICLE
AU  - Cordier, Fleur
AU  - Creytens, David
TI  - <em>RB1</em>: governor of the cell cycle in health and disease—a primer for the practising pathologist
AID  - 10.1136/jcp-2024-209480
DP  - 2024 Jul 01
TA  - Journal of Clinical Pathology
PG  - 435--438
VI  - 77
IP  - 7
4099  - http://jcp.bmj.com/content/77/7/435.short
4100  - http://jcp.bmj.com/content/77/7/435.full
SO  - J Clin Pathol2024 Jul 01; 77
AB  - RB1 stands as the pioneering discovery in tumour-suppressor genes, marking a pivotal breakthrough in comprehending cancer development. This overview delves into the role of RB1 in both health and disease, exploring its association with the tumourigenesis of various cancers and a distinct subset of soft-tissue neoplasms. Additionally, we discuss the application of immunohistochemistry and fluorescence in situ hybridisation to detect RB1 alterations.