RT Journal Article
SR Electronic
T1 <em>RB1</em>: governor of the cell cycle in health and disease—a primer for the practising pathologist
JF Journal of Clinical Pathology
JO J Clin Pathol
FD BMJ Publishing Group Ltd and Association of Clinical Pathologists
SP 435
OP 438
DO 10.1136/jcp-2024-209480
VO 77
IS 7
A1 Cordier, Fleur
A1 Creytens, David
YR 2024
UL http://jcp.bmj.com/content/77/7/435.abstract
AB RB1 stands as the pioneering discovery in tumour-suppressor genes, marking a pivotal breakthrough in comprehending cancer development. This overview delves into the role of RB1 in both health and disease, exploring its association with the tumourigenesis of various cancers and a distinct subset of soft-tissue neoplasms. Additionally, we discuss the application of immunohistochemistry and fluorescence in situ hybridisation to detect RB1 alterations.