Distribution of category ratings (top) and relative frequencies (bottom) of mean EGFR gene copy number in participating laboratories according the following cut-offs: (1) from 0 to ≤2, (2) between 2 and ≤3 and (3) ≥3 (κ=0.20168, SE=0.072)
Ratings* | |||||
Patient | Colorado | Rozzano | Locarno | Leuven | Milano |
1 | 3 | 3 | 3 | 3 | 3 |
2 | 3 | 2 | 3 | 3 | 3 |
3 | 3 | 3 | 2 | 2 | 2 |
4 | 3 | 2 | 3 | 2 | 2 |
5 | 3 | 2 | 3 | 1 | 2 |
6 | 3 | 3 | 3 | 3 | 3 |
7 | 3 | 2 | 2 | 2 | 1 |
8 | 3 | 2 | 3 | 3 | 3 |
9 | 3 | 2 | 3 | 3 | 2 |
10 | 2 | 2 | 2 | 1 | 1 |
11 | 2 | 1 | 2 | 2 | 1 |
12 | 2 | 2 | 2 | 1 | 2 |
Frequencies | |||||
Rating | Colorado (%) | Rozzano (%) | Locarno (%) | Leuven (%) | Milano (%) |
1 | 0 | 1 | 0 | 3 | 3 |
0 | 8.3 | 0 | 25.0 | 25.0 | |
2 | 3 | 8 | 5 | 4 | 5 |
25.0 | 66.7 | 41.7 | 33.3 | 41.7 | |
3 | 9 | 3 | 7 | 5 | 4 |
75.0 | 25.0 | 58.3 | 41.7 | 33.3 |
↵* Rating, categories: (1) 0 to ≤2, (2) 2 to ≤3 and (3) >3.
EGFR, epidermal growth factor receptor.