NRAS and BRAF mutations detected by the Idylla NRAS-BRAF mutation test
Gene | Exon | Codon | Mutation | Protein | Nucleotide change | Genetic call |
NRAS | 2 | 12 | G12D | p.(Gly12Asp) | c.35G>A | G12D |
G12C | p.(Gly12Cys) | c.34G>T | G12C | |||
G12S | p.(Gly12Ser) | c.34G>A | G12S | |||
G12A | p.(Gly12Ala) | c.35G>C | G12A/V | |||
G12V | p.(Gly12Val) | c.35G>T | ||||
13 | G13D | p.(Gly13Asp) | c.38G>A | G13D | ||
G13R | p.(Gly12Arg) | c.37G>C | G12R/V | |||
G12V | p.(Gly13Va) | c.38G>T | ||||
3 | 59 | A59T | p.(Ala59Thr) | c.175G>A | A59T | |
61 | Q61K | p.(Gln61Lys) | c.181A>G | Q61K | ||
Q61R | p.(Gln61Arg) | c.182A>G | Q61R | |||
Q61L | p.(Gln61Leu) | c.182A>T | Q61L | |||
Q61H | p.(Gln61His) | c.183A>T | Q61H | |||
Q61H | p.(Gln61His) | c.183A>T | ||||
4 | 117 | K117N | p.(Lys117Asn) | c.351G>C | K11N | |
K117N | p.(Lys117Asn) | c.351G>T | ||||
A146T | p.(Ala146Thr) | c.426G>A | A146T/V | |||
A146V | p.(Ala146Val) | c.437C>T | ||||
BRAF | 15 | 600 | V600E | p.(Val600Glu) | c.1799T>A | V600E/D |
V600E | p.(Val600Glu) | c.1799_1800delinsAA | ||||
V600D | p.(Val600Asp) | c.1799_1800delinsAC | ||||
600 | V600K | p.(Val600Lys) | c.1798_1799delinsAA | V600K/R | ||
V600R | p.(Val600Arg) | c.1798_1799delinsAA |