Table 3

Multivariate Cox regression model: n=26; LR χ²=66.38; df=15; p < χ² ≤0.00001

Variable	HR	P value	95% CI
Variable	HR	P value	Lower	Upper
Age	1.032	0.021	1.005	1.061
Stage
Ia	Base	Base	Base	Base
Ib	1.364	0.387	0.675	2.757
IIa	3.009	0.002	1.495	6.054
IIb	3.006	0.009	1.318	6.853
IIIa	2.665	0.003	1.390	5.110
Lymphovascular invasion	2.017	0.002	1.296	3.138
Visceral pleural invasion	0.873	0.565	0.549	1.388
Parietal pleural invasion	1.553	0.366	0.598	4.034
Adenocarcinoma subtype
Lepidic	Base	Base	Base	Base
Acinar	1.066	0.830	0.595	1.911
Papillary	0.814	0.688	0.298	2.222
Micropapillary	1.390	0.346	0.701	2.755
Solid	1.644	0.137	0.854	3.163
Intra-alveolar spread (STAS)	289.6	0.009	4.202	19 961.07
Interaction variables
Lymphovascular invasion and parietal pleural invasion	4.855	0.019	1.302	18.10
STAS and age	0.921	0.011	0.865	0.981