Clinicopathological characteristics of intrahepatic cholangiocarcinoma patients stratified for Alb-ISH
| Total | Alb-ISH neg. | Alb-ISH pos. | P value | ||
| All patients | 151 | 46 | 105 | ||
| Age | Median | 62.2 | 61.9 | 62.20 | 0.916 |
| IQR | 53.6–86.2 | 52.5–68.2 | 53.8–82.2 | ||
| Sex | Male | 83 | 27 (58.7) | 56 (53.3) | 0.596 |
| Female | 68 | 19 (41.3) | 49 (46.7) | ||
| Histology | Ductal | 77 | 25 (54.4) | 52 (49.5) | 0.029* |
| Solid | 51 | 11 (23.9) | 40 (38.1) | ||
| Papillary | 9 | 3 (6.5) | 6 (5.7) | ||
| Clear cell | 7 | 1 (2.2) | 6 (5.7) | ||
| Mucinous | 3 | 3 (6.5) | 0 (0.0) | ||
| Signet ring | 3 | 3 (6.5) | 0 (0.0) | ||
| Adenosquamous | 1 | 0 (0.0) | 1 (1.0) | ||
| Subtype | Small duct | 91 | 17 (37.0) | 74 (70.5) | 0.0001 |
| Large duct | 60 | 29 (73.0) | 31 (29.5) | ||
| UICC | UICC 1 | 5 | 2 (7.1) | 3 (5.7) | 0.063† |
| UICC 2 | 30 | 6 (21.4) | 24 (45.3) | ||
| UICC 3 | 31 | 19 (67.9) | 22 (41.5) | ||
| UICC 4 | 5 | 1 (3.6) | 4 (7.5) | ||
| NA | 70 | 18 | 52 | ||
| pT | T1 | 19 | 8 (17.4) | 11 (10.5) | 0.049‡ |
| T2 | 90 | 20 (43.5) | 70 (66.7) | ||
| T3 | 26 | 11 (23.9) | 15 (14.3) | ||
| T4 | 16 | 7 (15.2) | 9 (8.5) | ||
| pN | N0 | 46 | 13 (46.4) | 33 (63.5) | 0.161 |
| N1 | 34 | 15 (53.6) | 19 (36.5) | ||
| NX | 71 | 18 | 53 | ||
| M | M0 | 146 | 45 (97.8) | 101 (96.2) | 1.000 |
| M1 | 5 | 1 (2.2) | 4 (3.8) | ||
| G | G1 | 7 | 1 (2.2) | 6 (5.7) | 0.563§ |
| G2 | 100 | 30 (65.2) | 70 (66.7) | ||
| G3 | 44 | 15 (32.6) | 29 (27.6) | ||
| R | R0 | 83 | 21 (53.8) | 62 (66.7) | 0.173¶ |
| R1 | 46 | 18 (46.2) | 28 (30.1) | ||
| R2 | 3 | 0 (0.0) | 3 (3.2) | ||
| RX | 19 | 7 | 12 | ||
| L | L0 | 70 | 21 (45.7) | 49 (46.7) | 1.000 |
| L1 | 81 | 25 (54.3) | 56 (53.3) | ||
| V | V0 | 43 | 16 (34.8) | 27 (25.7) | 0.327 |
| V1 | 108 | 30 (65.2) | 78 (74.3) | ||
| Pn | Pn0 | 113 | 31 (67.4) | 82 (78.1) | 0.221 |
| Pn1 | 38 | 15 (32.6) | 23 (21.9) | ||
| Overall survival | Median survival in years (n) | 4.2 (131) | 3.8 (36) | 4.2 (95) | . |
Unless otherwise noted, data are depicted as absolute numbers (%). P values were calculated using Fisher’s exact test excluding missing data (NA, NX, RX). Bold p values denote statistical significance.
To achieve sufficient group sizes for statistical analysis, subgroups were pooled for selected criteria and comparisons carried out as follows:
*Ductal+mucinous+signet ring+papillary versus solid+adenosquamous+clear cell.
†UICC1+2 versus UICC3+4.
‡pT1+2 versus pT3+4.
§G1+2 versus G3.
¶R0 versus R1+2.
Alb-ISH neg./pos., albumin in situ hybridisation negative/positive; G, grade of differentiation; L/V, invasion into lymphatic or blood vessels; M, distant metastases; pN, histopathologic lymph node evaluation; Pn, perineural invasion; pT, histopathologic tumour stage evaluation; R, resection margins; UICC 1-4, Union for International Cancer Control stages 0–4.