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Unrepresentative astrocytoma biopsy sampling is partly overcome by assessment of the MIB-1-labelled growth fraction
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  • Published on: 18 April 2016
    Non-invasive estimation of glioma proliferation by 99mTc-Tetrofosmin brain SPECT
    • GEORGE A ALEXIOU, UNIVERSITY HOSPITAL OF IOANNINA, DEPART. OF NEUROSURGERY
    • Other Contributors:
      • Spyridon Tsiouris, Konstantinos S. Polyzoidis, Athanasios P. Kyritsis, Andreas D. Fotopoulos

    Dear Editor

    An interesting recent article by Sheehan et al. in your journal investigated whether the MIB-1 (Ki-67) labelling index in astrocytoma tissue cores – designed to replicate unrepresentative biopsies – could provide valuable information concerning tumor grade. The authors studied 134 cases of glioma and found that Ki-67 may be used to exclude low-grade astrocytoma, but cannot be used to distinguish between gli...

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    Conflict of Interest:
    None declared.