Predicting the likelihood of a BRCA1/2 pathogenic variant being somatic by testing only tumour DNA in non-mucinous high-grade epithelial ovarian cancer

Robert D Morgan; George J Burghel; Nicola Flaum; Michael Bulman; Philip Smith; Andrew R Clamp; Jurjees Hasan; Claire Mitchell; Zena Salih; Emma R Woodward; Fiona Lalloo; Joseph Shaw; Sudha Desai; Emma J Crosbie; Richard J Edmondson; Helene Schlecht; Andrew J Wallace; Gordon C Jayson; D Gareth R Evans

doi:10.1136/jcp-2022-208369

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Original research

Predicting the likelihood of a BRCA1/2 pathogenic variant being somatic by testing only tumour DNA in non-mucinous high-grade epithelial ovarian cancer

Authors

Robert D Morgan Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester, UK PubMed articles Google scholar articles
George J Burghel North West Genomic Laboratory Hub, Manchester University NHS Foundation Trust, Manchester, UK PubMed articles Google scholar articles
Nicola Flaum Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester, UK North West Genomic Laboratory Hub, Manchester University NHS Foundation Trust, Manchester, UK Division of Evolution, Infection and Genomics, University of Manchester, Manchester, UK PubMed articles Google scholar articles
Michael Bulman North West Genomic Laboratory Hub, Manchester University NHS Foundation Trust, Manchester, UK PubMed articles Google scholar articles
Philip Smith North West Genomic Laboratory Hub, Manchester University NHS Foundation Trust, Manchester, UK PubMed articles Google scholar articles
Andrew R Clamp Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester, UK Division of Cancer Sciences, University of Manchester, Manchester, UK PubMed articles Google scholar articles
Jurjees Hasan Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester, UK PubMed articles Google scholar articles
Claire Mitchell Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester, UK PubMed articles Google scholar articles
Zena Salih Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester, UK PubMed articles Google scholar articles
Emma R Woodward North West Genomic Laboratory Hub, Manchester University NHS Foundation Trust, Manchester, UK Department of Clinical Genetics, Manchester University NHS Foundation Trust, Manchester, UK PubMed articles Google scholar articles
Fiona Lalloo North West Genomic Laboratory Hub, Manchester University NHS Foundation Trust, Manchester, UK Department of Clinical Genetics, Manchester University NHS Foundation Trust, Manchester, UK PubMed articles Google scholar articles
Joseph Shaw Department of Histopathology, Manchester University NHS Foundation Trust, Manchester, UK PubMed articles Google scholar articles
Sudha Desai Department of Histopathology, The Christie NHS Foundation Trust, Manchester, UK PubMed articles Google scholar articles
Emma J Crosbie Division of Cancer Sciences, University of Manchester, Manchester, UK Department of Gynaecological Surgery, Manchester University NHS Foundation Trust, Manchester, UK PubMed articles Google scholar articles
Richard J Edmondson Division of Cancer Sciences, University of Manchester, Manchester, UK Department of Gynaecological Surgery, Manchester University NHS Foundation Trust, Manchester, UK PubMed articles Google scholar articles
Helene Schlecht North West Genomic Laboratory Hub, Manchester University NHS Foundation Trust, Manchester, UK PubMed articles Google scholar articles
Andrew J Wallace North West Genomic Laboratory Hub, Manchester University NHS Foundation Trust, Manchester, UK PubMed articles Google scholar articles
Gordon C Jayson Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester, UK Division of Cancer Sciences, University of Manchester, Manchester, UK PubMed articles Google scholar articles
D Gareth R Evans North West Genomic Laboratory Hub, Manchester University NHS Foundation Trust, Manchester, UK Division of Evolution, Infection and Genomics, University of Manchester, Manchester, UK Department of Clinical Genetics, Manchester University NHS Foundation Trust, Manchester, UK PubMed articles Google scholar articles

Correspondence to Dr Robert D Morgan, Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester M20 4BX, UK; robert.morgan7{at}nhs.net

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Citation

Morgan RD, Burghel GJ, Flaum N, et al

Predicting the likelihood of a BRCA1/2 pathogenic variant being somatic by testing only tumour DNA in non-mucinous high-grade epithelial ovarian cancer

Journal of Clinical Pathology 2023;76:684-689.

Publication history

Received May 2, 2022
Accepted June 9, 2022
First published June 23, 2022.

Online issue publication

October 18, 2023

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