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Molecules in pathogenesis
Adipophilin: roles in physiology and pathology
  1. Feng-Zeng Li,
  2. Sheng Fang
  1. Dermatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
  1. Correspondence to Dr Sheng Fang; fangshengderm{at}163.com

Abstract

Adipophilin (ADRP/ADPH/PLIN2), an adipocyte differentiation-related protein, is highly expressed at a very early time during the differentiation of adipocytes. It assists in the formation and maintenance of intracellular lipid droplets and plays a role in regulating the physiological functions of the body. More and more studies indicate that it is involved in the occurrence and development of a variety of glycolipid metabolic diseases and tumours. In this review, we comprehensively stated the expression and functions of adipophilin and introduced its roles in physiology and pathology.

  • pathology, molecular
  • skin diseases
  • pathology, surgical

https://doi.org/10.1136/jcp-2022-208677

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    Footnotes

    • Handling editor Runjan Chetty.

    • Contributors F-ZL and SF: Conceptualisation. F-ZL and SF: Writing of the manuscript—original draft. F-ZL and SF: Writing of the manuscript—review and editing. All authors have read and agreed to the published version of the manuscript.

    • Funding Our research associated with this review was supported by the Chongqing medical scientific research project (Joint project of Chongqing Health Commission and Science and Technology Bureau), (2022QNXM014).

    • Competing interests None declared.

    • Provenance and peer review Commissioned; externally peer reviewed.