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Gene of the month
Gene of the month: VSTM2A
  1. Lisha Wang1,
  2. Osman Yilmaz1,
  3. Brendan A Veeneman2,
  4. Yuping Zhang3,4,
  5. Saravana M Dhanasekaran3,4,
  6. Rohit Mehra3,4
  1. 1 Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
  2. 2 Synthetic Lethality Research Unit, Oncology, GlaxoSmithKline, Cambridge, Massachusetts, USA
  3. 3 Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA
  4. 4 Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan, USA
  1. Correspondence to Dr Rohit Mehra, Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA; mrohit{at}med.umich.edu

Abstract

The V-set and transmembrane domain containing 2A (VSTM2A) gene is located on chromosome 7. In the physiological state, VSTM2A regulates preadipocyte cell differentiation. VSTM2A is highly expressed in normal human brain tissue and minimally expressed in other normal tissues. Mucinous tubular and spindle cell carcinoma (MTSCC) of the kidney is a distinct renal tumour subtype with signature chromosomal copy number alterations and an indolent outcome in the majority of cases. VSTM2A overexpression is highly enriched in this renal cancer subtype and has been shown to have potential diagnostic value in distinguishing MTSCC from renal tumours with overlapping histological appearances.

  • Kidney Neoplasms
  • Genes, Neoplasm
  • In Situ Hybridization

https://doi.org/10.1136/jcp-2023-208839

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    Footnotes

    • SMD and RM are joint senior authors.

    • Handling editor Vikram Deshpande.

    • Twitter @lishawang9

    • LW and OY contributed equally.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests None declared.

    • Provenance and peer review Commissioned; externally peer reviewed.